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Amylin via area postrema, GLP-1 via vagal signalling

Skopelitou et al., 2012a,b)

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Starting GHK-CU during extreme weather, cold dry winter or hot humid summer, adds environmental stress to the adjustment period

Since 90% of the bodys serotonin originates in the gut, these peripheral effects could influence central serotonergic tone through vagal signaling